Genetic Ancestry in Lung-Function Predictions
نویسندگان
چکیده
منابع مشابه
Genome-wide genetic ancestry measurements to predict lung function in European populations.
A.L. Lazaar, B.E. Miller, G. Francombe, A. Duvoix, S.A. Natanek and M.I. Polkey Clinical Discovery, Respiratory Therapy Area, GlaxoSmithKline, King of Prussia, PA, USA. Clinical Statistics Respiratory, GlaxoSmithKline, Uxbridge, Dept of Medicine, University of Cambridge, Cambridge Institute for Medical Research, Wellcome Trust/MRC Building, Cambridge, and NIHR Respiratory Biomedical Research Un...
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African-Americans have smaller lung function compared with European-Americans. The aim of this study was to disentangle the contribution of genetics from other variables on lung function. A cohort was followed from birth to 30 years of age in Brazil. Several variables were collected: genomic analysis based on DNA; forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) obtained b...
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The human genome is a mosaic with respect to its evolutionary history. Based on a phylogenetic analysis of 23,210 DNA sequence alignments from human, chimpanzee, gorilla, orangutan, and rhesus, we present a map of human genetic ancestry. For about 23% of our genome, we share no immediate genetic ancestry with our closest living relative, the chimpanzee. This encompasses genes and exons to the s...
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Recent statistical and computational analyses have shown that a genealogical most recent common ancestor (MRCA) may have lived in the recent past [Chang, J.T., 1999. Recent common ancestors of all present-day individuals. Adv. Appl. Probab. 31, 1002-1026. 1027-1038; Rohde, D.L.T., Olson, S., Chang, J.T., 2004. Modelling the recent common ancestry of all living humans. Nature 431, 562-566]. Howe...
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ژورنال
عنوان ژورنال: New England Journal of Medicine
سال: 2010
ISSN: 0028-4793,1533-4406
DOI: 10.1056/nejmoa0907897